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Information of biblio record :BL
Language of Text,Soundtrack etc.:English
Record identifier:2056
Personal Name:Senn, Stephen.
Title and statement of responsibility and:Statistical issues in drug development /\ Stephen Senn.
Publication:Chichester, England ;Hoboken, NJ :: John Wiley & Sons,, c2007.
Edition Statement:2nd ed.
Physical Description:xix, 498 p. ::ill. ;;25 cm.
Series:Statistics in practice
Internal Bibliographies/Indexes:Includes bibliographical references and index.
Contents Note:A brief and superficial history of statistics for drug developers -- Design and interpretation of clinical trials as seen by a statistician -- Probability, Bayes, P-values, tests of hypotheses, and confidence intervals -- The work of the pharmaceutical statistician -- Allocating treatments to patients in clinical trials -- Baselines and covariate information --
The measurement of treatment effects -- Demographic subgroups : representation and analysis -- Multiplicity -- Intention to treat, missing data and related matters -- One-sided and two-sided tests and other issues to do with significance and P-values -- Determining the sample size -- Multicentre trials -- Active control equivalence studies --
Meta-analysis -- Cross-over trials -- n-of-1 trials -- Sequential trials -- Dose-finding -- Concerning pharmacokinetics and pharmacodynamics -- Bioequivalence studies -- Safety data, harms, drug monitoring, and pharmaco-epidemiology -- Pharmaco-economics and portfolio management -- Concerning pharmacogenetics, pharmacogenomics, and related matters.
International Standard Book Number (ISBN):9780470018774 (cloth : alk. paper)
0470018771 (cloth : alk. paper)
Topical Name Used as Subject:Drug development-- Statistical methods.
Topical Name Used as Subject:Clinical Trials as Topic.
Topical Name Used as Subject:Drug Design.
Topical Name Used as Subject:Statistics as Topic-- methods.
LCC:‭RM301.25‬‭.S46 2007‬
Dewey Decimal Classification: